Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor

Protein Data Bank Japan2024-10-16 更新2026-03-21 收录

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Crystal structure of the VEGFR2 kinase domain in complex with a 2,3-dihydro-1,4-benzoxazine inhibitor Descriptor: N-(4-CHLOROPHENYL)-7-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]-2,3-DIHYDRO-1,4-BENZOXAZINE-4-CARBOXAMIDE, Vascular endothelial growth factor receptor 2 Authors: Whittington, D.A, Long, A.M, Rose, P, Zhao, H. Deposit date: 2007-10-18 Release date: 2008-04-08 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Novel 2,3-dihydro-1,4-benzoxazines as potent and orally bioavailable inhibitors of tumor-driven angiogenesis. J.Med.Chem., 51, 2008

血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2, VEGFR2）激酶域与2,3-二氢-1,4-苯并噁嗪类抑制剂结合的晶体结构描述符：N-(4-氯苯基)-7-[(6,7-二甲氧基喹啉-4-基)氧基]-2,3-二氢-1,4-苯并噁嗪-4-甲酰胺作者：Whittington D.A.、Long A.M.、Rose P.、Zhao H. 提交日期：2007-10-18 发布日期：2008-04-08 最后修改日期：2024-10-16 检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.65埃（Å）引用文献：《新型2,3-二氢-1,4-苯并噁嗪类强效口服生物可利用肿瘤驱动血管生成抑制剂》，《药物化学杂志》（J.Med.Chem.），第51卷，2008年

创建时间：

2007-10-18