PLA2G15 hydrolyses LPC to GPCho and LCFA(-)

Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the esterification of plasma cholesterol. Group XV phospholipase A2 (PLA2G15 aka LCAT-like lysophospholipase, LLPL or lysosomal phospholipase A2, LPLA2) bears 49% sequence similarity to LCAT (Taniyama et al. 1999) and is present in plasma. PLA2G15 possesses both calcium-independent phospholipase A(2) and transacylase activities (Abe & Shayman 1998) and could hydrolyse lysophosphatidylcholine (lysoPC), a proatherogenic lipid, to glycerophosphorylcholine (GPCho) and a free fatty acid anion (LCFA(-)) (Taniyama et al. 1999, Hiraoka et al. 2002).

卵磷脂胆固醇酰基转移酶（LCAT）是血浆胆固醇酯化过程中的关键酶。第XV族磷脂酶A2（PLA2G15，又称LCAT样溶血磷脂酶，LLPL或溶酶体磷脂酶A2，LPLA2）与LCAT具有49%的序列相似度（Taniyama等，1999），并存在于血浆中。PLA2G15同时具备钙非依赖性磷脂酶A(2)和转酰基酶活性（Abe & Shayman，1998），并能将溶血磷脂酰胆碱（lysoPC），一种促粥样硬化的脂质，水解为甘油磷酸胆碱（GPCho）和游离脂肪酸阴离子（LCFA(-)）（Taniyama等，1999，Hiraoka等，2002）。