Crystal Structure of GSK3b in complex with inhibitor 15R

Crystal Structure of GSK3b in complex with inhibitor 15R Descriptor: (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION, ... Authors: Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) Deposit date: 2013-02-01 Release date: 2013-03-20 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.702 Å) Cite: Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published

GSK3β与抑制剂15R的复合物晶体结构 组分描述：(2R)-2-(1H-吲哚-3-基甲基)-1,4-二氢吡啶并[2,3-b]吡嗪-3(2H)-酮、糖原合成酶激酶3β（Glycogen synthase kinase-3 beta）、磷酸根离子（PHOSPHATE ION）等。作者：Zhan, C、Wang, Y、Wach, J、Sheehan, P、Zhong, C、Harris, R、Patskovsky, Y、Bishop, J、Haggarty, S、Ramek, A、Berry, K、O'Herin, C、Koehler, A.N、Hung, A.W、Young, D.W、Almo, S.C，纽约结构基因组学研究联盟（New York Structural Genomics Research Consortium, NYSGRC）。提交日期：2013-02-01；发布日期：2013-03-20；最后更新日期：2024-11-06。研究方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.702埃（Å）。引用文献：采用多样性导向合成的片段筛选策略获得GSK3β抑制剂，待发表。