Pathways differentially regulated in multiple brain regions in patients infected with HIV without NCI as compared to uninfected controls.

The table shows pathways dysregulated in at least 2 brain regions in patients infected with HIV without NCI compared to uninfected controls. The dataset was interrogated for pathway enrichment using the canonical pathways from the MSigDb C2 collection using GSEA. The GSEA pathway analysis results show gene expression changes involving significant immune activation and neuronal injury even in the absence of clinical NCI. NES: normalized enrichment score; FDR: false discovery rate; WM: White Matter; FC: Frontal Cortex; BG: Basal Ganglia.