Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 1 blood group A-tetrasaccharide (E558A, X01 mutant)

Protein Data Bank Japan2023-12-20 更新2026-03-21 收录

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Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 1 blood group A-tetrasaccharide (E558A, X01 mutant) Descriptor: 1,2-ETHANEDIOL, GLYCOSIDE HYDROLASE, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Kwan, D.H, Constantinescu, I, Chapanian, R, Higgins, M.A, Samain, E, Boraston, A.B, Kizhakkedathu, J.N, Withers, S.G. Deposit date: 2014-11-11 Release date: 2014-11-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.03 Å) Cite: Towards Efficient Enzymes for the Generation of Universal Blood Through Structure-Guided Directed Evolution. J.Am.Chem.Soc., 137, 2015

结合1类血型A四糖（E558A、X01突变体）的98家族糖苷水解酶（glycoside hydrolase）催化模块（Sp3GH98）的晶体结构描述符：1,2-乙二醇、糖苷水解酶、α-L-岩藻吡喃糖-(1-2)-[2-乙酰氨基-2-脱氧-α-D-半乳糖吡喃糖-(1-3)]β-D-半乳糖吡喃糖-(1-3)-2-乙酰氨基-2-脱氧-β-D-葡萄糖吡喃糖作者：Kwan, D.H.、Constantinescu, I.、Chapanian, R.、Higgins, M.A.、Samain, E.、Boraston, A.B.、Kizhakkedathu, J.N.、Withers, S.G. 沉积日期：2014-11-11 发布日期：2014-11-26 最后修改日期：2023-12-20 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.03埃引用文献：《通过结构指导定向进化制备通用血型用高效酶》，《美国化学会志》，137卷，2015年

创建时间：

2014-11-11