Draft genome sequences of Helicobacter pylori isolate cultured from one patient with chronic gastritis.. Helicobacter pylori HPARG63

The complete genome sequencing of strain HPARG63 was performed by sequencing technology-454 (with a coverage of 100X ) and "de novo" assembly. 34 contigs with a total size of approximately 1,668,716 bp, G+ C content of 38.79%, and 1623 coding sequences, were respectively obtained. Almost 50% of the coding sequences were recorded within the different subsystems defined functions. Major virulence markers, vacA, cag pathogenicity island (cagPAI), and several outer membrane proteins of the Hop family, were annotated. In addition comB SSTIV was also annonated. The strain harboured a whole cagPAI with genetic rearrangements similar to those found in the H. pylori B8 strain. The strain HPARG63 contain two types of plasticity zone (PZ), one similar to PZ1 of H. pylori strain P12 and the other showed remnants of PZ type 2.