Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors
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https://figshare.com/articles/dataset/Discovery_of_Leucyladenylate_Sulfamates_as_Novel_Leucyl-tRNA_Synthetase_LRS_-Targeted_Mammalian_Target_of_Rapamycin_Complex_1_mTORC1_Inhibitors/4219608
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资源简介：
Recent studies indicate
that LRS may act as a leucine sensor for
the mTORC1 pathway, potentially providing an alternative strategy
to overcome rapamycin resistance in cancer treatments. In this study,
we developed leucyladenylate sulfamate derivatives as LRS-targeted
mTORC1 inhibitors. Compound 18 selectively inhibited
LRS-mediated mTORC1 activation and exerted specific cytotoxicity against
colon cancer cells with a hyperactive mTORC1, suggesting that 18 may offer a novel treatment option for human colorectal
cancer.
创建时间：
2016-11-09
