Evaluation of the effects of aspirin at plasma concentrations on embryo development using zebrafish model

we exposed zebrafish embryos to plasma - level concentrations of aspirin and observed dose-dependent decreases in heart rate, body length and locomotor activity ( measured by movement speed and distance).Through transcriptomic,we try to outlines potential mechanisms linking differentially expressed genes and molecular modifications, providing a novel reference for evaluating the potential impacts of plasma - level aspirin concentrations on fetal development and guiding its clinical use during pregnancy