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Data From: Dietary restriction extends lifespan across different temperatures in the fly

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DataONE2024-03-28 更新2024-06-08 收录
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Dietary restriction (DR) has been consistently shown to extend lifespan across a range of taxa. However, recent findings question the universality of the DR longevity response, suggesting DR may not extend lifespan at lower temperatures in flies, and that the DR longevity response is an artifact of benign laboratory conditions.  We re-test this hypothesis, measuring the lifespan of Drosophila melanogaster at the lab-standard 25°C, and at colder temperatures (18°C and 21°C) across a range of 5 diets.  We found the DR longevity response to be robust, extending lifespan irrespective of temperature. Fecundity was measured as a positive control for the DR phenotype, and it was found that DR reduced egg laying. We suggest results that question DR as a phenotype should not be overinterpreted readily, as variations in the experimental setup, genetic lines used, and diet-lifespan reaction norm may be responsible for discrepancies. Additionally, starting conditions that show a lifespan extension ..., , , # Data From: Dietary restriction extends lifespan across different temperatures in the fly We have submitted our raw data for our survival curves showing the longevity response of yw flies to dietary restriction at standard lab temperatures. (Lifespan_25°C_ywRflies.csv), cold temperatures (Lifespan_18°Cand21°C_ywRflies.csv), and their fecundity at cold temperatures (EggCounting_18°Cand21°C_ywRflies.csv). Data is presented in an accepted manuscript for Functional Ecology. ## Descriptions **Lifespan Data** The following details are the same across both lifespan datasets: * Individual: Cox proportional hazard model requires that each row in the dataset represents a single individual. * Genotype: The code M22 is used by the lab to refer to a wild-type strain of Drosophila melanogaster known as ywR flies. * Cage: Number assigned to the demography cage each fly was kept in. This was recorded so Cage could then be included as a random term in our Cox proportional hazard model. * A...
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2025-07-29
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