Cardiovascular risk in patients with type 2 diabetes is associated with alteration of blood monocyte phenotype and plasma metabolome

To gain insight into the relationship between circulating monocytes and cardiovascular risk (CV) progression in patients with type 2 diabetes (T2D), we collected blood monocytes (CD14 positive selection) from 92 people with type 2 diabetes and coronary artery calcium score (CAC-score). Gene expression profiles of circulating monocytes were assessed by RNA sequencing. We included RNA-Seq samples from circulating monocytes of 92 patients with type 2 diabetes, stratified into four groups according to their CV risk assessed by CAC-score: very low with CAC-score = 0 (CV0 group), low with CAC-score between 1 and 100 (CV1 group), intermediate with CAC-score between 101 and 400 (CV2 group), and high with CAC-score greater than 400 (CV3 group). **Submitter declares that the raw data files were not submitted because the RNA-seq data are the property of the Assistance Publique - Hôpitaux de Paris, who did not provide permission for the deposit of the raw sequence data**