Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... Authors: Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2019-05-30 Release date: 2019-08-07 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020

人类双孔域钾离子通道TASK-1（K2P3.1）结合抑制剂BAY 1000493的闭合构象晶体结构。配体描述：1,2-二酰基-sn-甘油-3-磷酸胆碱、胆固醇半琥珀酸酯、癸基-β-D-麦芽吡喃糖苷等。作者：Rodstrom, K.E.J、Pike, A.C.W、Zhang, W、Quigley, A、Speedman, D、Mukhopadhyay, S.M.M、Shrestha, L、Chalk, R、Venkaya, S、Bushell, S.R、Tessitore, A、Burgess-Brown, N、Arrowsmith, C.H、Edwards, A.M、Bountra, C、Carpenter, E.P，结构基因组学联盟（Structural Genomics Consortium, SGC）。存入日期：2019年5月30日，发布日期：2019年8月7日，最后修改日期：2024年1月24日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.9 Å。引用文献：《TASK通道的低开放X门将抑制剂捕获于孔穴内》，《自然》（*Nature*），第582卷，2020年