HLA-association to transformed JCV nOD levels in Scandinavian cohort.

Results from the linear regression analysis of the association between HLA-alleles and JCV nOD levels. Only alleles that are nominally significant (ptable 5 are presented. P-values that reach nominal significance, 0.05 are marked in bold. The median nOD levels are given among individuals positive or negative for respective HLA allele. In the crude analysis each allele was analysed on its own, adjusted for gender and age. Age at sampling was divided into four categories, 18–29, 30–39, 40–49, and 50 and older, with group 40–49 as the reference. The analysis was performed in R version 2.15.1 [50]. *Multivariate: all nominally significant alleles from the same gene in the same model, adjusted for age and gender. † Median nOD is given among individuals positive or negative for respective HLA allele.Common extended HLA haplotypes were selected from those published in the literature for the Caucasian population [19]–[21]. Alternative common DRB1*15 haplotypes DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*03, DQB1*06:02-DQA1*01:02-DRB1*15-B*51-C*?-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*51-C*?-A*11. The DQB1*03:01-DQA1*05-DRB1*11-B*51-A*02 haplotype exist with many different C alleles, C*05 not being the most common one.