GWAS in Fibrosing Interstitial Lung Disease

This study was a case-control genome-wide association study of 1616 non-Hispanic white cases and 4683 controls. Under an additive model for the minor allele at each SNP, we identified 19 SNPs, representing 7 chromosomal locations (5p15, 6p24, 7q22, 11p15, 15q14-15, 17q21, and 19p13), with genome-wide significant (P < 5x10-8) associations using the discovery samples included in this submission. We genotyped the 19 genome-wide significant SNPs in addition to 178 SNPs with 5x10-8 < P-value <.0001 and found 4 additional loci (3q26, 4q22, 10q24, and13q34) with genome-wide significant SNPs in the meta-analysis.]]> Analysis description: We performed a case-control GWAS of 1,616 cases and 4,683 controls (genotypes for the controls are not approved for release to dbGaP). All subjects were whole-genome genotyped on a Illumina Human 660W Quad BeadChip assay. Disease status for cases was determined using criteria established by the American Thoracic Society/European Respiratory Society.We used standard criteria established by the American Thoracic Society/European Respiratory Society in 2001 (Am J Respir Crit Care Med., 2002) to determine diagnostic classification of all patients in the discovery and replication phases. We excluded cases with known explanations for development of fibrotic IIP including infections, systemic disorders, or relevant exposures (e.g. asbestos). We included only non-Hispanic white participants.]]> This study release consists of "cases" only, as approval to deposit "controls" was not available.]]>