Pharmacokinetics of Understudied Drugs Administered to Children per Standard of Care - Doxycycline

Aim: Characterize the PK of doxycycline administered to children per standard of care as prescribed by their treating caregiver.

Methods: The PK and safety analyses was conducted for doxycycline data from NICHD-2011-POP01, a multicenter, prospective opportunistic PK study of understudied drugs in children less than 21 years of age who receive drugs per standard of care, as prescribed by a treating caregiver. The NICHD-2011-POP01 study enrolls participants under multiple drugs of interest (DOI) including doxycycline, and is actively enrolling participants.

Results: A one-compartment model offered the best fit to characterize doxycycline PK data based on model selection criteria. No AEs or SAEs related to study procedures were reported.