Roles of B cell c-Maf signaling in regulating anti-tumor immunity

Transcription factor c-Maf has been suggested to contribute to the regulation of IL-10 in regulatory B cells, but the role of B cell c-Maf signaling in anti-tumor immunity and regulating antibody responses remain unknown. Here, we used control and conditional B cell c-Maf KO mice and collected B cells from pancreas of KPC tumor-bearing mice as well as lymph nodes of B16.F10 tumor-bearing mice or tumor free mice. The differentially expressed genes were determined by RNA sequencing.