Changes of virion dimensions upon particle disassembly measured by cryo-ET

1Condition refers to the different stages and conditions of VV disassembly as described in the text. n�Cthe number of tomograms used for a given condition; if more than one particle was used for measurement, the average value and standard deviations (in brackets) are shown. The outer virion dimensions as well as the dimensions of the cores were measured in the tomograms of differently oriented particles, and are shown separately.2Shape refers to the shape of the core that can be dumbbell (db)-or ovoid-shaped. The spikes are arranged periodically (ordered) in intact VV, but loose this arrangement (random) if the outer membranes detach from the core. The DNA is condensed (cond.) and tightly aligned along the core membrane under all conditions, except in virions that bind to the cell surface, where the DNA fills the entire core space (��spread��)3Width�C��1st end�� and ��2nd end�� represent measurements of the core width taken at two broadest dimensions of the dumbbell-shaped cores, or at the equivalent positions in the cores that were ovoid-shaped. ��Width middle�� represents the narrow, middle, part of the core or its equivalent in ovoid-shaped cores.1' refers to virions incubated together with the cells, but that do not contact the plasma membrane, such as the particles found at the side of the grid devoid of cells.