Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism

Chronic inflammation underpins many human diseases. The morbidity and mortality of chronic inflammation is often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an important temporal cross-talk between these systems. Here, we show that inflammatory arthritis results in rhythmic joint inflammation and drives major changes in muscle and liver energy metabolism and rhythmic gene expression. Overall design: RNA-Seq from mRNA of mouse liver, muscle and joint across the course of a day. Time-series include mRNA profiles from DBA/1 mice with collagen-induced arthritis (CIA) on day 7 after the development of disease symptoms and also at matched time points in naïve control mice.