Parameters characterizing mitral spike responses to CCK receptor agonists.

First three rows list descriptive parameters under control conditions for three classes of CCK-8S spike response: excitatory, mixed excitatory-suppressive, and suppressive (data pooled for 300 nM and 1 µM CCK-8S; there was no significant difference between the two concentrations). For multiphasic responses caused by spike inactivation (e.g. Fig. 3C), duration of excitation was calculated using the end of the second excitatory peak. Next two rows list parameters of spike responses to 1 µM CCK-8S recorded in the presence of blockers of fast synaptic transmission. Last three rows list parameters of responses to 1 µM CCK-4, for 3 spike response classes: excitatory, mixed excitatory-suppressive, and suppressive. Values are expressed as mean ± SEM. Latencies were measured from time of CCK perfusion switch (including ∼50–80 s perfusion lag) to time of deviation from mean basal spike rate (p