Genome-wide maps of CD14-dependent and CD14-independent bladder innate immune responses to UPEC. Mus musculus

We report a transcriptional response in the mouse bladder that encompasses multiple innate immune networks not previously associated with CD14. Major CD14-dependent pathways included immune cell trafficking, differential cytokine production in macrophages, and IL-17 signaling Overall design: We used RNA-based sequencing technology for high-throughput profiling of innate immune responses in mouse bladder and the role of CD14 in these responses