Additional file 5: of Integrated analysis of genetic, behavioral, and biochemical data implicates neural stem cell-induced changes in immunity, neurotransmission and mitochondrial function in Dementia with Lewy Body mice

Pathways_altered_in_ASO_mice_and_NSC_transplantation. Significant differentially regulated pathways between treatment groups summarized in Table S3. The analysis based on GSEA result and CluGo group term cluster annotation which determines the most representative GO term of a cluster of similar biological processes. The first column describes experimental group contrasts, the second columns indicates the significantly differentially expressed module gene sets (Additional file 4) between conditions; the third, fourth and fifth columns contain pathway information of annotated gene sets. Table contains potential dysregulated pathways associated with ASO genotype that are significantly different between ASO-Veh and WT-Veh conditions and pathways that are altered differently in ASO-Veh and ASO-NSC conditions. The overlap of pathway and Module eigegenes direction (Fig. 1, Additional file 4: tab6) between the two contrasts suggest that NSC treatment can alter ASO associated pathways. Pathways that are altered differently in ASO-NSC and WT-NSC conditions suggest an ASO genotype interaction with NSC treatment. (XLSX 359 kb)