Impaired taurine transport contributes to the development of bronchopulmonary dysplasia

Sprague-Dawley rat pups were used to study the effect of taurine supplementation on hyperoxia-exposed lungs. The study, which was conducted with meticulous attention to detail, found significant effects of taurine supplementation. Rat pups were randomly assigned to room air (NOX) and >90% oxygen (HOX) from postnatal day 1 (P1) to P10. Half of the pups of each group received a daily taurine (100 mg/kg) intraperitoneal injection or an equal volume of PBS (two by two design). The four groups were NOX-PBS, NOX-taurine, HOX-PBS, and HOX-taurine. At P10, a comprehensive range of methodologies was employed, including morphometrics, histology, metabolomics, and immunoblots. Two pups, one male and one female, were randomly selected for single-cell RNA sequencing at P10