Microarray analysis on human neuroblastoma cells exposed to iron, B-amyloid or the B-amyloid iron complex. Homo sapiens

Microarray analysis on human neuroblastoma cells exposed to iron, B-amyloid or the B-amyloid iron complex. Alzheimer's disease is associated with an abnormal accumulation of certain metal ions. Overall design: Analysis used a neuronal cell lines, the SH-SY5Y, exposed to either AB, the AB-Fe complex or Fe alone. The SH-SY5Y without treatment were used that a control. For the exposure to AB, six replicates were performed (three dye swap and three non-dye swap), while for exposure to AB-Fe and Fe two replicates each were made (one dye swap and one non-dye swap).