Bradykinin receptors B1 and B2 bind to bradykinin

Bradykinin (Rocha e Silva M, et al, 1949) is a 9 amino-acid peptide belonging to the kinin group of proteins. It causes blood vessel dilation via the release of prostacyclin, nitric oxide and endothelial-derived hyperpolarizing factor, resulting in lower blood pressure. It is also involved in the pain mechanism. Bradykinin exerts its effects through two receptors, bradykinin receptor B1 and 2 (B1R and B2R respectively). B1R (Menke JG et al, 1994) is synthesized de novo following tissue injury and receptor binding leads to an increase in cytosolic calcium concentration, resulting in chronic and acute inflammatory responses. Unlike B1R, B2R (Hess JF et al, 1992) is ubiquitously and constitutively expressed in healthy tissues. It also increase cytosolic calcium concentration and stimulates the mitogen-activated protein kinase pathways.

布拉迪基宁（Rocha e Silva M, 等人，1949年）是一种属于激肽族蛋白的由9个氨基酸组成的肽。它通过释放前列环素、一氧化氮和内皮衍生性超极化因子引起血管扩张，从而降低血压。此外，它还参与疼痛机制。布拉迪基宁通过两种受体发挥其作用，即布拉迪基宁受体B1和B2（分别简称为B1R和B2R）。B1R（Menke JG 等人，1994年）在组织损伤后重新合成，受体结合导致细胞质钙浓度增加，引发慢性及急性炎症反应。与B1R不同，B2R（Hess JF 等人，1992年）在健康组织中普遍且恒定表达。它同样会增加细胞质钙浓度，并刺激丝裂原活化蛋白激酶途径。