Expression profiles of circRNAs in peripherial blood mononuclear cells from cryptococcal meningitis and healthy individuals.

CircRNAs are a recently well-known regulator that mediates a variety of biological processes. Cryptococcus neoformans is an environmental fungal pathogen that can cause fatal cryptococcal meningitis in immunocompromised individuals. However, the involvement of circRNA in cryptococcal infection remains unclear. In this study, high‐throughput microarray was performed to identify the circRNA expression profile in cryptococcal meningitis patients. Three cryptococcal meningitis (CN) patientsand healthy individuals (HC) were included and PBMCs were isolated by Ficoll-10771 (Sigma Aldrich, USA) according to the manufacturer’s manual. All samples were stored at -80°C before experiments.