IKKbeta phosphorylates IkB causing NF-kB to dissociate

IkB is an inhibitory protein that sequesters NF-kB in the cytoplasm, by masking a nuclear localization signal, located just at the C-terminal end in each of the NF-kB subunits. A key event in NF-kB activation involves phosphorylation of IkB by an IkB kinase (IKK). NGF stimulates the activity of the IkB kinase IKK-beta, and, possibly, IKK-alpha as well. Once IkB is phosphorylated, the IkB:NF-kB complex dissociates.

IkB是一种抑制蛋白，通过掩盖位于每个NF-kB亚基C端末端的核定位信号，将NF-kB隔离于细胞质中。NF-kB激活的关键事件之一涉及IkB被IkB激酶（IKK）磷酸化。神经生长因子（NGF）刺激IkB激酶IKK-β的活性，可能还包括IKK-α。一旦IkB被磷酸化，IkB:NF-kB复合物便会解离。