Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Canis lupus familiaris
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA299599
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To infer potential epigenetic variations during SCNT procedure that could occur and lead to abnormal sex-reversal phenotype, we performed whole genome bisulfite sequencing (WGBS) on DNAs extracted from primary fibroblast cells isolated from seven dog samples. These samples include two normal donors, two sex-reversed cloned dogs, one sex-reversed re-cloned dog as well as a pair of independent replicate samples taken as controls Overall design: Comparing between sex-reversal SCNT-generated dogs with their original donors
创建时间：
2015-10-21
