Identification of a novel microRNA panel associated with metastasis following radical prostatectomy for prostate cancer

This is a case control study designed to identify microRNA sequences associated with metastasis following radical prostatectomy for clinically localized prostate cancer. Samples were obtained from patients with clinical evidence of metastatic disease following surgery (cases) and patients who showed no evidence of metastasis or biochemical recurrence at least 5 years following surgery (controls). Cases and controls were matched for tumor grade and duration of follow-up. Overall design: Next generation whole miRNome sequencing of 19 metastatic and 19 non-metastatic prostate cancer.