A novel TLX1 driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models

We generated a new rag2-TLX1 driven T-ALL model in zebrafish. RNA sequencing was preformed on the developed TLX1 T-ALLs (sequencing performed in the Speleman lab). In addition, RNA sequencing was performed on various additional zebrafish T-ALL models (shrek, hulk, otg, hMYC, sequenced in the Frazer lab) to look at the molecular differences between the various existing T-ALL models. RNA sequencing data from TLX1, shrek, hulk, otg T-ALL samples, wild type thymocytes sequenced in the Speleman lab, wild type thymocytes sequenced in the Frazer lab. Shrek, otg, hulk, hMYC preleukemic thymocytes