Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845
收藏Protein Data Bank Japan2023-11-29 更新2026-03-21 收录
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Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845 Descriptor: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ... Authors: Xu, M, Zhang, X, Xu, L, Chen, S. Deposit date: 2020-10-19 Release date: 2021-01-13 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
结核分枝杆菌苯丙氨酰-tRNA合成酶（phenylalanyl-tRNA synthetase）与化合物PF-3845复合物的晶体结构
描述符：N-吡啶-3-基-4-[[3-[5-(三氟甲基)吡啶-2-基]氧基苯基]甲基]哌啶-1-甲酰胺、苯丙氨酰-tRNA连接酶（Phenylalanyl-tRNA ligase）α亚基、苯丙氨酰-tRNA连接酶（Phenylalanyl-tRNA ligase）β亚基……
作者：Xu M、Zhang X、Xu L、Chen S
保藏日期：2020-10-19
发布日期：2021-01-13
最后修改日期：2023-11-29
检测方法：X射线衍射（2.3 Å）
引用文献：《PF-3845作为抑制结核分枝杆菌苯丙氨酰-tRNA合成酶的新型化学骨架的再发现》，《生物化学杂志（J. Biol. Chem.）》，2021
创建时间：
2020-10-19
