Intravenous injection of CTHs triggers the systemic release of CLXC9 and CXCL10.

CTHs (25 mg/kg body weight) or PBS was injected intravenously into Balb/c mice (5 mice per group). After 4h (A) and 24h (B), mice were euthanized and blood samples were recovered by cardiac puncture followed centrifugation. The resulting plasma samples from each group were pooled and analyzed using a mouse multi-cytokine array (n = 1). Mean pixel densities were quantified by Image Lab 4.1 (Bio-Rad Laboratories, Berkeley, CA, USA).