Biologic Treatment Outcomes in Refractory Chronic Urticaria: A Systematic Review

Chronic Urticaria is an allergic condition of the skin characterized by recurrent, pruritic wheals and angioedema spanning at least 6 weeks. Initial treatment involves the use of oral antihistamine therapy, with adjunct leukotriene receptor antagonist therapy in severe cases. Systemic biologics are often reserved for patient’s refractory to initial therapy. This systematic review examines the treatment outcomes of systemic biologics in patients with refractory chronic urticaria.