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The identification and functional annotation of RNA structures conserved in vertebrates

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP090297
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We report the genome-wide screen of the vertebrate genomes for conserved RNA structures (CRSs) by CMfinder [Yao et al. Bioinformatics 2006] and predict around 515k human genomic regions that harbor such structures. For a customized CaptureSeq experiment 125k probes of 60bp length were synthesized for both strands. These probes target 77k CRS regions, which were selected by largest CRS prediction score (pscores), more than 3 substitutions to their closest genomic paralog, and conservation in human and mouse. Overall design: Expression analysis by customized CaptureSeq
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2017-09-17
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