Frequencies of translocation following creation of double-strand breaks by HO endonuclease during serial growth of wild type and mutant diploidsa.

aThe median translocation frequency was determined for each strain from at least 12 independent cultures. Fold differences from the median frequency obtained with the wild type strain with the same substrates, located at the same genomic positions, and at equivalent time-points are indicated in parentheses. The 95% confidence intervals are indicated in brackets. Pre-senescence corresponds to approximately 25 generations, senescence corresponds to approximately 60 generations, and post-senescence corresponds to approximately 100–125 generations.bTranslocation substrates were as described in the Materials and Methods. The frequencies for the rad1Δ/rad1Δ(XV/III), rad52Δ/rad52Δ(XV/III) and rad59Δ/rad59Δ(XV/III) strains have been previously reported [43].cFrequency not determined (ND).