COSMOS Data Cohorts

COSMOS Study - TCGA Patient Barcodes Study: A 24-month biological transition from proliferation to immune dominance in cancer recurrence Files Description 1- TCGA BRCA Validation Cohort Code.csv TCGA Breast Invasive Carcinoma patients used for transcriptomic validation N = 1096 patients Columns: patient_id, cancer_type, os_time_days, os_time_months, os_status, temporal_phase 2- TCGA LUAD Validation Cohort.csv TCGA Lung Adenocarcinoma patients used for transcriptomic validation N = 513 patients Columns: patient_id, cancer_type, os_time_days, os_time_months, os_status, temporal_phase 3- TCGA patient cohort (complete list).csv Extended Cox regression analysis across 9 TCGA cancer types Filter: Overall survival follow-up ≥605 days (≈20 months) N = 2871 patients across 9 cancer types Cancer types: BRCA, COAD, HNSC, KIRC, LIHC, LUAD, LUSC, STAD, UCEC Columns: patient_id, cancer_type, os_time_days, os_time_months, os_status, temporal_phase Data Sources Clinical outcomes: TCGA-CDR (Liu et al., Cell 2018, DOI: 10.1016/j.cell.2018.02.052) Original data: NCI Genomic Data Commons (https://portal.gdc.cancer.gov) Temporal Phase Definition Early (≤24m): Patients with overall survival ≤24 months Late (>24m): Patients with overall survival >24 months Code Availability https://github.com/Sjtu-Fuxilab/COSMOS