Comparison of transcriptional changes in CD103 positive dendritic cells in mice lacking Il33 expression in DCs relative to control mice

IL33 is an alarmin protein that is known to be released by epithelial cells as a response to damage. There is also evidence that dendritic cells express IL33, however its function in these cells is not well understood. To investigate the distinct function of IL33 in dendritic cells, deep sequencing of mRNA transcripts was conducted on FACS sorted DCs in mice lacking Il33 expression in CD11c expressing cells compared to control mice. Overall design: 4 samples total, 2 samples per condition, CD11c-cre-IL33flx/flx versus CD11c-cre