Cortical propagation as a biomarker for recovery after stroke

Each .zip file refers to a different mouse group. Groups are defined accordingly to the paper. A .zip file contains a .mat file (matlab) associated to each mouse and each day of recording. The .mat files are "structure arrays" containing the following fields: - force: vector (time x 1), force applied by the mouse to the handle; - status: vector (time x 1), discrete codification of the current phase of the passive extension and active retraction cycle, see Table S1 in the Supporting Information of the paper; - index: vector (pixels x 1), position of pixels in the 200x200 matrix of the recorded calcium; - calcium: matrix (time x pixels), calcium fluorescence; - day: number, relative day from lesion. The 3-dimensional matrix of the 2-D calcium imaging over time can be calculated as (in matlab) dataMatrix=zeros(size(dataMouse.calcium,1),200,200); dataMatrix(:,dataMouse.index)=dataMouse.calcium; Resolution of images in the mat file is 60 um/pixel. Bregma is located at image coordinates 100, 75. Stroke coordinates : 0.5 mm AP 1.75 mm ML from bregma : image coordinates 129 (100+1750/60), 67(75-500/60)每个.zip压缩文件对应一个独立的小鼠实验组，实验组的划分依据本论文中的定义。每个压缩文件内包含若干.mat文件（MATLAB格式），分别对应每只小鼠以及每一次记录的日期。此类.mat文件为结构数组，包含以下字段：- force（力）：一维向量（维度为时间步长×1），表示小鼠对操作手柄施加的作用力；- status（状态）：一维向量（维度为时间步长×1），对被动伸展与主动收缩循环的当前阶段进行离散编码，详细说明可参见论文支撑信息中的表S1；- index（索引）：一维向量（维度为有效像素数×1），标记钙信号成像200×200矩阵内有效像素的位置；- calcium（钙荧光信号）：二维矩阵（维度为时间步长×有效像素数），存储钙荧光信号数据；- day（相对天数）：数值型变量，表示从造模（损伤）操作起的相对天数。可通过以下MATLAB代码将二维钙成像数据重构为三维时间序列矩阵：dataMatrix=zeros(size(dataMouse.calcium,1),200,200); dataMatrix(:,dataMouse.index)=dataMouse.calcium; 该.mat文件中图像的分辨率为60 μm/像素。前囟（Bregma）的图像坐标为(100, 75)。损伤灶坐标（相对于前囟）为：前后轴0.5 mm、内侧-外侧轴1.75 mm，对应的图像坐标为(129, 67)，具体计算式为100+1750/60、75-500/60。