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Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition

ChEBI2014-06-04 更新2026-07-21 收录

表观遗传靶向治疗

Hedgehog信号通路

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-58185 数据链接链接失效反馈

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Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition

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创建时间：

2014-06-04

帕金森病分子机制

Hedgehog信号通路

Previously, we showed that cholinergic interneurons of the dorsal striatum lose cilia in mice harboring the Parkinsonâs disease associated, kinase activating, R1441C LRRK2 mutation (Dhekne et al., 2

DataONE2021-11-22 更新80

MRTF/SRF link the cytoskeleton and hedgehog pathway in drug-resistant basal cell carcinomas

化疗耐药机制

Hedgehog信号通路

We use multi-dimensional genomic analysis using mouse resistant BCCs to identify a non-canonical hedgehog activation pathway driven by the transcription factor, serum response factor (SRF). RNA and wh

NIAID Data Ecosystem50

Table_2_Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus.DOCX

γδT细胞分化

Hedgehog信号通路

Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in

NIAID Data Ecosystem30

Combined constitutive canonical and non-canonical HH signaling caused by depletion of Patched 2 causes an MPN phenotype and transforms chronic MPNs into acute leukemias

Hedgehog信号通路

骨髓增殖性肿瘤转化机制

Combined constitutive canonical and non-canonical HH signaling caused by depletion of Patched 2 causes an MPN phenotype and transforms chronic MPNs into acute leukemias

ChEBI2016-01-11 更新60

Novel chromobox 2 inhibitory peptide decreases tumor progression

表观遗传靶向治疗

多肽药物设计

The Polycomb Repressor Complex 1 (PRC1) is an epigenetic regulator of differentiation and development, consisting of multiple subunits including RING1, BMI1, and Chromobox. The composition of PRC1 dic

Figshare2023-05-27 更新40

Targeting the epigenetic regulation of Hedgehog transcriptional output through BET bromodomain inhibition

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