Gene expression profiling of diffuse malignant peritoneal mesothelioma

Diffuse malignant peritoneal mesothelioma (DMPM) is a rapidly lethal malignancy. The comprehension of the molecular features of DMPM is of utmost importance for the fruitful management of the disease, especially in patients who fail standard treatments and have a poor prognosis due to the lack of effective alternative therapeutic options. Gene expression profiling was carried out on a series of 45 frozen surgical specimens of diffuse malignant peritoneal mesothelioma (DMPM), 3 normal peritoneum samples and 2 patient-derived cell lines.