Epidemiological data used in the model#

#HLA+ = carrier of ≥ 1 copy of the DRB1*1501 allele*From Canadian Data [21], based on a prevalence of 150 per 105 population and split into men and women according to [15]. Concordance rates presented as “proband-wise” rates [30].†Data unavailable on the 2 male patients [21]. The worst case is: 9/11 = 0.82**See: Prop. (1.4) of Appendix S1 (Section C)##Canadian HLA data: D Sadovnick (personal communication). Based on ∼ 3,000 cases and ∼ 400 Controls (% women not available). Control rates confirmed in a much larger transplant database.††UCSF Databases: J Oksenberg (personal communication) UCSF #1 (GeneMSA) - 485 cases (68% women) and 431 Controls (66% women) UCSF #2 (IMSGC) - 779 cases (76% women)