Semi-simulated TF pertubation in ATAC-seq datasets (Positive control)

Semi-simulated ATAC-seq data with TF pertubations of different pertubation strength. Pertubations in this dataset were only introduced in peaks overlapping a motif of the perturbed factor. The three .tar-files contain: DTFAB_sim_pos_beds.tar.gz: .bed files of the semi-simulated ATAC-seq fragments DTFAB_sim_pos_cm.tar.gz: count matrices (per peak counts of semi-simulated fragments) DTFAB_sim_pos_peaks.tar.gz: .bed files with ATAC-seq peak coordinates of semi-simulated fragments The folder structure of 1.,2. & 3. is of the following format <tf>_<pertubation paradigm>_<pertubation strength>. The original samples without any pertubation introduced are the same as in I. (pertubation strength) and only uploaded there. The original samples, for which biases & pertubations were introduced, were retrieved from ENCODE with following IDs: ENCFF495DQP, ENCFF130DND, ENCFF447ZRG, ENCFF966ELR, ENCFF358GWK, ENCFF963YZH. ChIP-seq peaks used to introduce perturbations correspond to following ENCODE identifiers: ENCFF156OCY, ENCFF592UDD, ENCFF250FJC, ENCFF500EWB. This semi-simulated datasets is belongs to a series of datasets: Dataset Description DOI I. pertubation strength TF pertubation with different strengths, no biases introduced 10.5281/zenodo.10732704 II. pos control (this) TF pertubation only introduced in (ChIP-) peaks with a motif of the respective TF. 10.5281/zenodo.10781849 III. fld TF pertubation with additionally introduced fragment length distribution bias 10.5281/zenodo.10781109 IV. gc TF pertubation with additionally introduced GC content bias 10.5281/zenodo.10781759