Hsp90a NTD covalently bound to sulfonyl fluoride 5 at K58
收藏Protein Data Bank Japan2024-11-13 更新2026-03-21 收录
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Hsp90a NTD covalently bound to sulfonyl fluoride 5 at K58 Descriptor: 3-{[(3S)-3-({6-amino-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}methyl)piperidin-1-yl]methyl}benzene-1-sulfonyl fluoride, Heat shock protein HSP 90-alpha Authors: Cuesta, A, Wan, X, Taunton, J. Deposit date: 2019-09-07 Release date: 2020-02-19 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90. J.Am.Chem.Soc., 142, 2020
Hsp90α N端结构域（Hsp90a NTD）在K58位点与磺酰氟（sulfonyl fluoride）5共价结合，描述项：3-{[(3S)-3-({6-氨基-8-[(6-碘-2H-1,3-苯并二氧杂环戊烯-5-基)硫基]-9H-嘌呤-9-基}甲基)哌啶-1-基]甲基}苯-1-磺酰氟，热休克蛋白HSP 90-α；作者：Cuesta, A、Wan, X、Taunton, J.；提交日期：2019-09-07；发布日期：2020-02-19；最后修改日期：2024-11-13；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.75 Å；引用文献：《配体构象偏倚驱动Hsp90表面暴露赖氨酸的对映选择性修饰》，J.Am.Chem.Soc., 142, 2020
创建时间：
2019-09-07
