Neuroinflammation_DNAseq

The goal of this project is to understand the causal link between cellular processes and Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. This study will use large scale mapping experiments to identify expression QTLs using variation from the HipSci resource of cell lines, and scRNAseq. We will then employ colocalization analysis (with for example AD/PD GWAS/GWAX data from OTAR037 and publically available data (Nicolas et al. 2018)) to map loci where the same causal genetic signal drives both disease risk and variation in a core microglial cell function.