MELANOCORTIN RECEPTOR ACCESSORY PROTEIN 2-INDUCED ADRENOCORTICOTROPIC HORMONE RESPONSE OF HUMAN MELANOCORTIN 4 RECEPTOR

Human (h) and zebrafish (zf) melanocortin receptor 4 (MC4R) activation data. Our data shows how both h and zfMC4R increase the sensitivity to the adrenocorticotropic hormone (ACTH) when interacting with the melanocortin receptor two accessory protein type 2 (MRAP2). Therefore, MC4R becomes an ACTH receptor in the presence of MRAP2 thus opening new gates to the stress effects mediated by ACTH. This MRAP2-induced ACTH sensitivity of MC4R is evolutionary conserved (zebrafish-human) thus suggesting a physiological role for the MC4R/MRAP2 interaction本数据集包含人类（h）与斑马鱼（zf）的黑皮质素4受体（melanocortin receptor 4, MC4R）激活数据。本研究数据表明，当与黑皮质素受体2型辅助蛋白（melanocortin receptor two accessory protein type 2, MRAP2）相互作用时，人类与斑马鱼MC4R对促肾上腺皮质激素（adrenocorticotropic hormone, ACTH）的敏感性均显著提升。据此，在MRAP2存在的条件下，MC4R可转变为ACTH受体，从而为阐释ACTH介导的应激效应开辟了全新的研究路径。此外，MRAP2诱导的MC4R对ACTH的敏感性在斑马鱼与人类之间具有进化保守性，这提示MC4R与MRAP2的相互作用具备重要生理功能。