Identification of differentially expressed mRNAs in HCSC cell lines compared with HCC cell lines
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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Hep3B and Huh7 are two types of human hepatoma cell lines (HCC). In our laboratory, we cultured their stem-like cancer cells (HCSCs), Hep3B-C and Huh7-C. And we have demonstrated that these cells had enhanced stem cell properties, drug resistance, properties of EMT, and stronger tumor-initiating capabilities. To explore functionally crucial mRNAs in HCSCs, 2 samples of HCSCs and 2 samples of HCCs were sequenced by the Illumina Genome Analyzer II. Through differential expression analysis, we finally identified 115 up- and 402 down-regulated miRNAs which were consistently up- and down-regulated in two stem cells compared to the cancer cells.
提供机构:
Eastern Hepatobiliary Surgery Hospital
创建时间:
2022-02-20



