Crystal structure analysis of cruzain with three Fragments: 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino-4,6-difluorobenzothiazole) and 9 (N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide).

Crystal structure analysis of cruzain with three Fragments: 1 (N-(1H-benzimidazol-2-yl)-1,3-dimethyl-pyrazole-4-carboxamide), 6 (2-amino-4,6-difluorobenzothiazole) and 9 (N-(1H-benzimidazol-2-yl)-3-(4-fluorophenyl)-1H-pyrazole-4-carboxamide). Descriptor: 4,6-difluoro-1,3-benzothiazol-2-amine, Cruzipain, N-(1H-benzimidazol-2-yl)-1,3-dimethyl-1H-pyrazole-4-carboxamide, ... Authors: Tochowicz, A, McKerrow, J.H, Craik, C.S. Deposit date: 2014-08-17 Release date: 2015-04-08 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Applying Fragments Based- Drug Design to identify multiple binding modes on cysteine protease. To Be Published

克鲁兹因（cruzain）与三种片段的晶体结构分析：1号片段为N-(1H-苯并咪唑-2-基)-1,3-二甲基吡唑-4-甲酰胺，6号片段为2-氨基-4,6-二氟苯并噻唑，9号片段为N-(1H-苯并咪唑-2-基)-3-(4-氟苯基)-1H-吡唑-4-甲酰胺。描述符：4,6-二氟-1,3-苯并噻唑-2-胺、克鲁兹因（Cruzipain）、N-(1H-苯并咪唑-2-基)-1,3-二甲基-1H-吡唑-4-甲酰胺…… 作者：Tochowicz, A、McKerrow, J.H、Craik, C.S. 提交日期：2014-08-17；发布日期：2015-04-08；最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION，3.27 Å）。引用文献：《基于片段的药物设计用于识别半胱氨酸蛋白酶的多种结合模式》（待发表）