Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB)

Orexin Receptor 2 (OX2R) in Complex with G Protein and Natural Peptide-Agonist Orexin B (OxB) Descriptor: Engineered Guanine nucleotide-binding protein subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Hong, C, Byrne, N.J, Zamlynny, B, Tummala, S, Xiao, L, Shipman, J.M, Partridge, A.T, Minnick, C, Breslin, M.J, Rudd, M.T, Stachel, S.J, Rada, V.L, Kern, J.C, Armacost, K.A, Hollingsworth, S.A, O'Brien, J.A, Hall, D.L, McDonald, T.P, Strickland, C, Brooun, A, Soisson, S.M, Hollenstein, K. Deposit date: 2020-12-15 Release date: 2021-02-10 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation. Nat Commun, 12, 2021

食欲素受体2（Orexin Receptor 2, OX2R）与G蛋白及天然肽类激动剂食欲素B（Orexin B, OxB）的复合物
描述：工程化鸟苷酸结合蛋白α亚基、鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ2、鸟苷酸结合蛋白G(I)/G(S)/G(T)亚基β1……
作者：Hong, C、Byrne, N.J、Zamlynny, B、Tummala, S、Xiao, L、Shipman, J.M、Partridge, A.T、Minnick, C、Breslin, M.J、Rudd, M.T、Stachel, S.J、Rada, V.L、Kern, J.C、Armacost, K.A、Hollingsworth, S.A、O'Brien, J.A、Hall, D.L、McDonald, T.P、Strickland, C、Brooun, A、Soisson, S.M、Hollenstein, K
存放日期：2020-12-15
发布日期：2021-02-10
最后修改日期：2024-11-20
实验方法：电子显微镜（3.2埃）
引用文献：活性态食欲素受体2的结构阐明肽类与小分子激动剂的识别及受体激活机制，《自然-通讯》，12卷，2021年