Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

Autophagy is a recycling program for cells to adapt to metabolic needs and to stress. Defects in autophagy can affect metabolism, aging, proteostasis and inflammation. We used microarrays to determine the changes in global gene expression in murine melanocyte upon genetic inactivation of the essential autophagy gene Atg7 and as secondary aim wheter the gene regulation by ultraviolet A light is affected by the Atg7 knockout This study was performed in biological duplicates for autophagy competent and deficient melanocytes.