PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with FMOMB000203a

PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with FMOMB000203a Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-fluoro-1,3-dihydro-2H-indol-2-one, Tyrosine-protein phosphatase non-receptor type 1 Authors: Mehlman, T, Biel, J, Azeem, S.M, Nelson, E.R, Hossain, S, Dunnett, L.E, Paterson, N.G, Douangamath, A, Talon, R, Axford, D, Orins, H, von Delft, F, Keedy, D.A. Deposit date: 2022-10-20 Release date: 2022-11-23 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B. Elife, 12, 2023

PanDDA分析团队提交的数据集——蛋白酪氨酸磷酸酶非受体1型（PTP1B）与FMOMB000203a复合物的晶体结构。相关描述组分包括：2-氨基-2-羟甲基丙烷-1,3-二醇、5-氟-1,3-二氢-2H-吲哚-2-酮、蛋白酪氨酸磷酸酶非受体1型（Tyrosine-protein phosphatase non-receptor type 1）。作者为Mehlman, T、Biel, J、Azeem, S.M、Nelson, E.R、Hossain, S、Dunnett, L.E、Paterson, N.G、Douangamath, A、Talon, R、Axford, D、Orins, H、von Delft, F、Keedy, D.A.。提交日期：2022-10-20；发布日期：2022-11-23；最后修改日期：2024-10-09。实验方法为X射线衍射（分辨率2.09埃）。引用文献：《室温晶体学揭示小分子片段与PTP1B的结合模式改变》，发表于Elife，第12卷，2023年。