InnateDB

InnateDB has been developed to facilitate systems level investigations of the mammalian (human, mouse and bovine) innate immune response. Its goal is to provide a manually-curated knowledgebase of the genes, proteins, and particularly, the interactions and signaling responses involved in mammalian innate immunity. InnateDB incorporates information of the whole human, mouse and bovine interactomes by integrating interaction and pathway information from several of the major publicly available databases but aims to capture an improved coverage of the innate immunity interactome through manual curation.先天免疫数据库（InnateDB）旨在支撑哺乳动物（人类、小鼠与牛）先天免疫应答的系统级研究。其核心目标是打造一个针对哺乳动物先天免疫相关基因、蛋白质，尤其是相关相互作用与信号应答过程的人工整理知识库。该数据库通过整合多个主流公开数据库的相互作用与通路信息，覆盖了人类、小鼠和牛的全相互作用组数据，并致力于通过人工整理进一步优化先天免疫相互作用组的覆盖完整性。

搜集汇总

背景与挑战

背景概述

InnateDB是一个公开可用的知识库，专注于人类、小鼠和牛的先天免疫反应，包含基因、蛋白质、实验验证的相互作用和信号通路。它通过整合公共数据库数据和手动整理，提高了先天免疫相互作用组的覆盖，并提供了系统层面的分析和可视化工具。