1–9 single base substitution mutational signatures of all nine polyps using deconstructSigs.

The top panel represents the mutational profile of the polyp and displays the proportion of mutations found in each trinucleotide context. The middle panel shows the reconstructed mutational profile created using deconstructSigs and by multiplying the calculated weights by the signatures. The bottom panel shows the error (SSE = sum-squared error) between the tumour mutational profile and the reconstructed mutational profile. (ZIP)